Starve-feed cycle has three stages: the post absorptive state after a meal, the early fasting during the night, and the refed state after breakfast. A major goal of the many biochemical alterations in this period is to maintain glucose homeostasis—that is, a constant blood-glucose level. Fasting involves a radical change in cellular physiology and metabolism. Blood glucose normally provides the body with sufficient energy through glycolysis. During a fast, maintenance of blood glucose levels initially relies on glycogen stores in the liver and skeletal muscle. Starvation states happen very rarely in generally well-nourished individuals. When the body is fed, glucose, fats, and proteins are absorbed across the intestinal membrane and enter the bloodstream and lymphatic system to be used immediately for fuel. Any excess is stored for later fasting stages.

Shivangi Ojha

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