What is the end product of nucleotide metabolism? The final product of the synthesis of both purine and pyrimidine nucleotides is ribonucleotide, which must be reduced further to the 2'-deoxy-form to be incorporated into the DNA. Ribonucleotide reductase catalyses this reaction in the presence of thioredoxin as a cofactor. Nucleotides have a central role in the physiology of organisms as building blocks of nucleic acids, storage of chemical energy, carriers of activated metabolites for biosynthesis, structural moieties of coenzymes and metabolic regulators. Nucleotide synthesis is important for medical intervention because it can block certain pathways for coming into play. For example it can block the pathway that is responsible for synthesising thymidylate which can help fight against cancer. Cancer is one of the big things that can be fought with this information.

Preena N

68 resources

1

0

1

Like