How much do you know about the pathology of Alzheimer's disease? Alzheimer's is a progressive disease beginning with mild memory loss and possibly leading to loss of the ability to carry on a conversation and respond to the environment. Neurofibrillary tangles are abnormal accumulations of a protein called tau that collects Inside neurons. Healthy neurons, in part, are supported internally by structures called microtubules, which help guide nutrients and molecules from the cell body to the axon and dendrites. In healthy neurons, tau normally binds to and stabilizes microtubules. In Alzheimer’s disease, however, abnormal chemical changes cause tau to detach from microtubules and stick to other tau molecules, forming threads that eventually join to form tangles inside neurons. These tangles block the neuron’s transport system, which harms the synaptic communication between neurons. Alzheimer's disease involves parts of the brain that control thought, memory, and language. Memory loss and confusion are the main symptoms. No cure exists, but medication and management strategies may temporarily improve symptoms.

Adarsh S

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